Inceptor regulates insulin homeostasis

A research team discovered Inceptor in 2021 and described its role as an inhibitor of the insulin signaling pathway. Both Inceptor and the insulin receptor are located on the surface of beta cells, where Inceptor can block the insulin receptor, thus reducing the cells’ insulin sensitivity and weakening the signaling pathway. The current study goes further, showing that Inceptor binds excess insulin within the beta cell and directs it towards degradation. “This knowledge about Inceptor’s function gives us a deeper understanding of how beta cells regulate their insulin homeostasis,” says the author.

The increased presence of Inceptor in beta cells suggests that the receptor plays a role in insulin secretion, which is regulated by beta cells. This process is often impaired in diabetes, leading to elevated blood sugar levels. By blocking Inceptor, the researchers were able to refill beta cells' insulin stores, enhance insulin release, and prevent beta cell death. “Especially in already damaged cells, blocking Inceptor could help boost insulin production and protect the beta cells,” explains the author.

The findings suggest that specifically targeting Inceptor could be a promising strategy for improving the function of insulin-producing cells in people with diabetes. “Our goal is to develop new medications that support the cells’ insulin balance and prolong their viability, based on our discovery”" says the author. Such a therapy could especially help individuals in the early stages of type 2 diabetes to slow disease progression and reduce the risk of complications.

To translate these findings from the lab to real-world applications, the researcher has founded a start-up. The company is working on developing drugs that specifically block Inceptor to protect or regenerate beta cells. Preclinical studies are initially needed to test the safety and efficacy of these new therapeutic approaches. “Our goal is to pave the way for clinical trials and thereby contribute to the treatment, and hopefully even the cure, of diabetes,” says the author.

https://www.nature.com/articles/s42255-024-01164-y

https://sciencemission.com/Inceptor-binds-to-and-directs-insulin-towards-lysosomal-degradation-in-%CE%B2-cells