Interorganelle phospholipid communication
Phospholipid homeostasis comprises an intricate network of communication between mitochondria, peroxisomes, the endoplasmic reticulum, and the Golgi apparatus.
Disruptions to the function of one type of organelle triggers cell-wide changes in the structures and functions of other organelles.
Volume electron microscopy (vEM) is an emerging technology that allows 3D visualization of organelle morphology and communication changes upon disruption of phospholipid homeostasis.
Mathematical descriptors of organelle morphology and interorganelle contacts can increase the depth of data obtained from vEM datasets and standardize analyses across the field.
Many organelle diseases share common pathological features, and organelle communication breakdown has been identified in many disease states such as Parkinson's disease.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(24)00168-1
https://sciencemission.com/Interorganelle-phospholipid-communication
