Ischemia derived extracellular vesicles drive non-infarcted region degeneration
It is not clear if penumbral hypoxia-induced EVs deliver pathogenic cargo to remote brain regions affecting acute ischemic stroke outcomes.
In a mouse model of focal ischaemia, the researchers show that extracellular vesicles released from the ischaemic penumbra carry pathogenic circular RNAs (CircOGDH) to remote thalamic regions, driving secondary degeneration beyond the infarct.
The authors demonstrate that cortical CircOGDH knockdown abolished thalamic CircOGDH accumulation and reversed neuronal loss and synaptic impairment, confirming its causal role in secondary damage.
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awag049/8471680
