Long-lived cellular molecules in the brain

Long-lived proteins (LLPs) and long-lived RNAs (LLRs) might be required for maintaining functional integrity and the longevity of long-lived cells in the brain, such as neurons and adult neural stem cells. 

Hypotheses have been raised regarding the functions of long-lived molecules, but current proposals are largely speculative and remain to be experimentally tested.

Based on the localization of LLPs/LLRs, they seem likely to be involved in synaptic and epigenetic regulation, which could be critical for long-term memory and the maintenance of cellular identity.

To dissect the physiological and pathological roles of LLPs/LLRs, novel methods are needed to measure them at subcellular resolution and manipulate them selectively.

Unraveling the mechanisms underlying LLP/LLR maintenance will also improve current understanding of lifespan regulation and the emergence of age-related diseases.

https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(25)00146-8

https://sciencemission.com/Long-lived-cellular-molecules-in-the-brain