Neuropeptide Y and its Y2 receptor gene therapy for epilepsy
Co-expressing NPY and its inhibitory receptor Y2 in excitatory hippocampal cells allows inhibitory autoregulation of glutamate release. Expression of both genes in granule cell mossy fiber terminals reduces the frequency and duration of seizures in the synapsin triple KO model of epilepsy.
The researchers developed a LV vector with minimal CamKinaseII promoter driving expression of NPY and its receptor Y2.
Vector administration in the dentate gyrus allows for efficient and nearly selective in vivo overexpression of NPY and Y2 receptor in granule cell mossy fiber terminals.
This reduces the frequency and duration of seizures in the synapsin triple KO model of epilepsy.
https://www.embopress.org/doi/full/10.1038/s44319-024-00244-0
