Cross-talk of inflammation and cellular senescence in osteoarthritis
Senescence acts as a mediator of inflammatory pathways in the onset and progression of osteoarthritis (OA). Understanding of OA pathogenesis is important for effective treatment.
In this review, the authors summarize the mechanisms and hallmarks of cellular senescence, describe the relationship between cellular senescence and inflammation.
They also discuss senescence-associated secretory phenotypes (SASP) and the effects of pro- and anti-inflammatory interventions on cellular senescence.
Additionally, the authors focus on various types of cellular senescence in OA, including senescence in cartilage, subchondral bone, synovium, infrapatellar fat pad, stem cells, and immune cells, elucidating their mechanisms and impacts on OA.
They also discuss potential strategy for promoting cartilage regeneration by targeting senescent cells in OA.
https://www.nature.com/articles/s41413-024-00375-z
https://sciencemission.com/senescence-and-osteoarthritis
