Right parabrachial nucleus mediates early-phase neuropathic pain development
The cellular and molecular mechanisms underlying lateral parabrachial nucleus (PBN) mediated neuropathic pain is not clearly understood.
The researchers identify that the right-sided, but not the left-sided, PBN plays a pivotal role in the early-phase development of neuropathic pain.
They also uncover tachykinin signaling as the key driver of this lateralization control. Inhibiting Tacr1-positive neurons, blocking Tacr1-encoding tachykinin 1 receptor (NK1R), or knocking down the Tacr1 gene in the right-sided, rather than left-sided, PBN alleviates neuropathic pain-induced sensory hypersensitivity.
https://www.cell.com/neuron/fulltext/S0896-6273(24)00878-X
https://sciencemission.com/right-parabrachial-nucleus-and-pain
