Peroxiredoxin 6 (PRDX6) contributes to selenocysteine metabolism and ferroptosis resistance
Selenium is crucial for cell function and ferroptosis prevention.
Selenocysteine (Sec) is taken up by the Sec carrier, selenoprotein P (SELENOP) and released to be metabolized via selenocysteine lyase (SCLY), producing selenide, a substrate for selenophosphate synthetase 2 (SEPHS2), which provides the essential selenium donor, selenophosphate (H2SePO3−), for the biosynthesis of the Sec-tRNA.
The researchers discovered that peroxiredoxin 6 (PRDX6) binds directly to selenide and promotes its efficient use, enhancing selenoprotein translation.
This discovery offers further possibilities for therapeutic exploitation, as higher PRDX6 expression correlates with the aggressive nature of certain neuroblastoma subtypes.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00867-0
https://sciencemission.com/PRDX6-contributes-to-selenocysteine-metabolism-and-ferroptosis-resistance
