Roles for primary cilia in synapses and neurological disorders

Primary cilium which are microtubule extensions are present in all neurons of all types including excitatory and inhibitory neurons. Glial cells, such as astrocytes and oligodendrocyte progenitor cells (OPCs) have cilia too. Electron microscopy study shows no cilia in microglia and mature oligodendrocytes of the cerebral cortex,

This review explores the diversity of primary cilia in the mature brain and their interrelationships with a multitude of cellular structures, including axons and synapses.

Ciliary-related dysfunctions in neurodegenerative diseases is summarized in this review, with a special emphasis on Parkinson’s disease (PD) and neuropsychiatric disorders.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00231-9

https://sciencemission.com/Roles-for-primary-cilia-in-synapses-and-neurological-disorders