Targeting senescent cells in cancer and age-related diseases
Aged, damaged or abnormal cells undergo a stress response called senescence to stop the growth of these cells. Thus, senescence has a crucial role in development, tissue maintenance and cancer prevention.
These senescent cells acquire senescence-associated secretory phenotype (SASP) and release factors that fuel chronic inflammation. Senescent cells have been targeted to treat varies age related diseases.
In this Review, the researchers describe various types of senotherapies, including senolytics that eliminate senescent cells, senomorphics that suppress the SASP, interventions that mitigate senescence and strategies that harness the immune system to clear senescent cells.
They also summarize how these approaches can be combined with cancer therapies, and discuss the challenges and opportunities in moving senotherapies into clinical practice.
https://www.nature.com/articles/s41573-024-01074-4
https://sciencemission.com/Senescence-as-a-therapeutic-target-in-cancer-and-age-related-diseases
