Familial Alzheimer mutations stabilize synaptotoxic g-secretase-substrate complexes

Devkota et al. find that mutations that cause hereditary Alzheimer’s disease, located in the substrate and protease that produce amyloid b-peptides, result in reduced proteolytic function and stabilized enzyme-substrate complexes. These stalled complexes trigger synaptic loss in C. elegans that is independent of amyloid b-peptide production.Read more

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Familial Alzheimer mutations stabilize synaptotoxic g-secretase-substrate complexes