Neuroendocrine gut–brain signaling in obesity

The gut–brain axis regulates behavior, physiology, and metabolism to ensure dynamic control of energy homeostasis. 

Single cell transcriptomics, optogenetics, and live imaging revealed a high degree of molecular and functional diversity of cell types comprising the gut–brain axis.

Central and peripheral gut peptides interact with vagal and hormonal signals allowing for cooperation, redundancy, as well as for independent signaling pathways.

Forebrain regions, notably the hypothalamus, intricately modulate brainstem neurocircuitries fine-tuning vagal feeding pathways.

History of high-fat diet consumption and obesity is associated with maladaptive changes in gut–brain communication in both mouse models and humans.

https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(24)00120-6

https://sciencemission.com/gut%E2%80%93brain-signaling-in-obesity