How intestinal cells regenerate during inflammatory diseases without tumor risk
Intestinal regeneration is a tightly regulated process driven by coordinated molecular and cellular interactions that maintain and restore epithelial barrier integrity.
The immune system plays context dependent and often contrasting roles in intestinal regeneration.
Many regenerative mechanisms are coopted by tumors to promote growth, plasticity, and resistance to therapy.
Immune and stromal cells support tumor growth in the gut, in part by reactivating signaling pathways normally involved in intestinal regeneration.
The liver X receptor unlinks regeneration and tumorigenesis by supporting epithelial cell proliferation upon damage while promoting antitumor immune responses.
Neuregulin 1 promotes barrier restoration by inducing a regenerative profile in normal but not in transformed, epithelial cells.
https://www.cell.com/trends/immunology/fulltext/S1471-4906(26)00129-8
