A role for peripheral glial in skin wound healing
Multiple cell types are involved in the skin wound healing.
The researchers show that repair glia in peripheral nerves are part of a regenerative niche in acute skin wounds.
This glial niche promotes skin wound healing by regulating innate immune cell recruitment, in particular releasing chemoattractant CCL2 proteins that attract monocytes and monocyte-derived macrophages, both critical for a successful repair process.
The authors also show that macrophages influence fibroblast proliferation and transition into myofibroblasts.
They demonstrate that depletion of repair glia as well as glia-specific deletion of CCL2 reduces the number of macrophages, leading to impaired fibroblast proliferation and diminished fibroblast-to-myofibroblast transition.
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00449-7
