An adhesion protein regulates excitatory synapse development
Cd99 molecule-like 2 (Cd99l2) is highly expressed in the brain and is a type I transmembrane protein that plays a role in the transmigration of leukocytes across vascular endothelial cells but its role in the brain remains elusive.
The researchers reveal that neuronal Cd99l2 suppresses immediate-early gene expression through the CREB and SRF transcription factors while promoting dendritic branching and excitatory synapse development.
This pathway is essential for regulating synaptic transmission and plasticity in the hippocampus and memory-related behaviors in mice.
Cd99l2 knockout mice exhibit impaired excitatory synaptic transmission and plasticity in the hippocampus, along with deficits in spatial memory and contextual fear conditioning.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01506-7
https://sciencemission.com/Cd99l2-regulates-excitatory-synapse-development
