3D hydrogel-based pancreatic cancer model with gas plasma technology
The researchers established 3D hydrogel-based pancreatic cancer models to evaluate the permeation characteristics of plasma generated reactive species and their biological significance.
Combined with z-resolved high-content imaging, 3D tumor models exhibit great translational potential to characterize penetration and downstream effects in a tissue-like environment.
Some short-lived gas plasma-derived reactive species, such as peroxy-nitrite, show profound penetration depths in 3D hydrogel models.
Gas plasma-derived reactive species also act laterally to inactivate tumor cells.
Catalase does not protect tumor organoids from gas plasma-induced toxicity, attributing hydrogen peroxide a negligible role in plasma cytotoxicity in tissues.
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(25)00265-3
