Acetylcholine - dopamine interaction dysregulated in mouse model of autism spectrum disorders
Basal ganglia dysfunction potentially causes behavioral alterations in ASD.
The researchers show that the eIF4E Tg mouse model of ASD exhibits behavioral inflexibility and impaired striatal dopamine release, linked to disrupted b2-nAChR function on DA axons.
Thus, altered striatal ACh-DA interactions constitute a cellular basis for ASD-like behavioral inflexibility.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01348-2
