Alcohol consumption and aging brain!
Balance of excitation and inhibition in the cortex is disrupted in alcohol use disorder (AUD) leading to cognitive decline but the role of alcohol use on excitation and inhibition on the aging brain is not well understood.
The authors show that moderate voluntary alcohol use disrupts prefrontal cortical signaling at protracted ages in mice.
They demonstrate that glutamatergic events onto GABA neurons are increased 6 months following alcohol exposure and pyramidal and GABA neurons show altered intrinsic excitability 6 months after alcohol exposure.
Thus, moderate voluntary alcohol consumption influences the pre-disease environment in aging.
https://www.sciencedirect.com/science/article/pii/S0197458024001726
