Amino acid is a major carbon source for hepatic lipogenesis
The macronutrient driver of hepatic steatosis and metabolic dysfunction associated steatotic liver disease (MASLD) has not been fully defined.
The researchers identify high dietary protein consumption as a significant risk factor for MASLD/MASH in the NHANES study.
The authors further establish amino acids as a prime substrate fueling hepatic lipogenesis, as demonstrated through isotope tracing and a series of chemical, genetic, and dietary intervention studies.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00397-8
https://sciencemission.com/Amino-acid-is-a-major-carbon-source-for-hepatic-lipogenesis
