Amino acid is a major carbon source for hepatic lipogenesis
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The macronutrient driver of hepatic steatosis and metabolic dysfunction associated steatotic liver disease (MASLD) has not been fully defined.
The researchers identify high dietary protein consumption as a significant risk factor for MASLD/MASH in the NHANES study.
The authors further establish amino acids as a prime substrate fueling hepatic lipogenesis, as demonstrated through isotope tracing and a series of chemical, genetic, and dietary intervention studies.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00397-8
https://sciencemission.com/Amino-acid-is-a-major-carbon-source-for-hepatic-lipogenesis