Antiviral protein network identified using alphavirus infection
The interaction of viral RNA (vRNA) with host cell components are not clear yet.
The researchers apply complementary approaches to elucidate the composition of Sindbis virus ribonucleoproteins.
They identified a subset of nuclear RNA binding proteins (RBPs) that selectively translocate to the cytoplasm, interact with viral RNA, and strongly suppress viral gene expression.
Among them, U2 small nuclear RNP (U2 snRNP) emerges as a ribonucleoprotein complex contributing to the recognition of the vRNA and the antiviral infection.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00920-1
