Apolipoprotein E in Alzheimer’s disease

Three major isoforms ε2 < ε3 < ε4 of Apolipoprotein E (APOE- gene; apoE- protein) confer risk for Alzheimer’s disease (AD).  But APOE Christchurch and the COLBOS variant of REELIN are the protective gene variants.

In addition to its primary function in lipid transport, apoE influences amyloid-β (Aβ) aggregation, tau pathology, neuroinflammation, autophagy, cerebrovascular integrity and protection from lipid peroxidation and the resulting ferroptotic cell death.

In this review, the authors explore the multifaceted roles of apoE in AD pathogenesis, therapeutic targeting of apoE-mediated pathways.

https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-025-00843-y

https://sciencemission.com/ApoE-in-Alzheimer%E2%80%99s-disease-5953