Macrophage-induced enteric neurodegeneration

This study investigates the impact of myenteric neuron-macrophage interactions on postoperative trauma and subsequent motility disturbances, i.e., postoperative ileus.

The authors show that gut surgical trauma activates myenteric neurons.

They also demonstrate that abdominal surgery causes enteric neurodegeneration by inducing neuron death and synaptic damage in the enteric nervous system of the small intestine.

In addition, the researchers show that a neurodegenerative environment in the gut is created by  inflammatory macrophages and depletion of resident macrophages reduces surgery-induced enteric neurodegeneration and improves clinical symptoms.

Surgical patients show a comparable neurodegenerative profile in the gut.

https://www.embopress.org/doi/full/10.1038/s44321-024-00189-w

https://sciencemission.com/Macrophage-induced-enteric-neurodegeneration