Association between gut mycobiome and cardiometabolic health
The association between the gut mycobiome and cardiometabolic health remains underappreciated.
In a cohort of 12,641 Chinese participants, the researchers characterize the gut mycobiome’s composition and dynamics, demonstrating its connection to cardiometabolic health.
The authors found that fungal alpha diversity indices and 19 mycobiome genera are the major contributors to the mycobiome-cardiometabolic disease link. Saccharomyces emerged as an effect modifier of traditional risk factors in promoting type 2 diabetes risk.
They also identify several metabolites such as γ-linolenic acid and L-valine potentially mediating the association of the gut mycobiome with type 2 diabetes.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00518-4
