Autophagy, aging, and age-related neurodegeneration

The process in which damaged cell contents are degraded and recycled is called autophagy.

Upregulation of autophagy ameliorates neurodegeneration as toxic proteins are degraded and recycled.

Autophagy inhibition also induces neuronal and glial senescence, a phenomenon that occurs with increasing age in non-diseased brains as well as in response to neurodegeneration-associated stresses. Aging and many neurodegeneration-associated proteins and mutations impair autophagy.

How autophagy interacts with aging, senescence, and neurodegenerative diseases in a temporal, cellular, and genetic context is important for the future clinical application of autophagy-modulating therapies in aging and neurodegeneration.

https://www.cell.com/neuron/fulltext/S0896-6273(24)00663-9

https://sciencemission.ayurmatrika.com/Autophagy,-aging,-and-age-related-neurodegeneration