Autophagy-dependent versus autophagy-independent ferroptosis
Autophagy regulates the activity or levels of key players in ferroptosis, including glutathione peroxidase 4, SLC7A11, acyl-CoA synthetase long-chain family member 4, and ferritin.
Lysosomes exert multiple effects on ferroptosis through autophagy-dependent and -independent regulation of iron homeostasis, cathepsin B release, and TFEB activity.
The effect of mitophagy on ferroptosis is complicated by multiple contributions of mitochondria in ferroptosis: reactive oxygen species, iron storage, availability of unsaturated (phospho)lipid fueled by tricarboxylic acid cycle and phosphatidylethanolamine synthesis.
Additional pathways that induce the cooccurrence of autophagy and ferroptosis are revealed; for example, mammalian target of rapamycin complex 1, calcium balance, and p53.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00005-4
