Bacteriophage defense system proteases
A broad spectrum of bacterial phage defense systems featuring proteases likely still awaits discovery, showcasing diverse mechanisms for sensing, effector activation, and function.
Unlike traditional DNA or RNA editing, activatable proteases present new avenues for engineering biological systems through specific and direct modification of proteins.
Engineering proteases and their substrates opens possibilities for manipulating protein processing and function.
Adaptation of protease systems to other targets and pathways offers significant potential for protein signaling pathways and cell process regulation.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00247-6
