Brain cancer malignancy fueled by myelin recycling in macrophages
Tumor microenvironment (TME) plays a critical role in the growth of glioblastoma.
The researchers carried multi-omics analyses of TME and identified metabolically rewired tumor-associated macrophage (TAM) subpopulations with pro-tumorigenic properties.
Recycling of cholesterol-rich myelin debris by macrophages leads to the emergence of lipid-laden macrophages (LLMs) in glioblastoma.
The authors found that LLMs support glioblastoma malignancy through transfer of myelin-derived lipids to tumor cells, fueling cancer cell proliferation and recurrence.
https://www.cell.com/cell/fulltext/S0092-8674(24)00824-9
https://sciencemission.com/Macrophage-mediated-myelin-recycling-fuels-brain-cancer-malignancy
