Central amygdala-to-pre-Bötzinger complex neurotransmission is direct and inhibitory
The mechanisms on how emotions regulate breathing behavior is not clearly understood.
The researchers demonstrate a direct relationship between the central amygdala, and the brainstem pre-Bötzinger complex,which generates the fundamental rhythm and pattern for breathing. The connection between these two sites is monosynaptic and inhibitory, involving GABAergic central amygdala neurons.
This pathway may provide a mechanism to inhibit breathing in the context of freezing to assess threats and plan defensive action and may explain how epileptic seizures invading the amygdala cause long-lasting apnea, which can be fatal.
