Central neuropathic pain
Central somatosensory nervous system lesion may lead to central neuropathic pain.
Based on the cause the central neuropathic pain differs and the mechanisms that underlie central neuropathic pain are not fully understood.
Modulation of neuronal activity, neuron–glia and neuro-immune interactions and targeting pain-related alterations in brain connectivity, represent potential therapeutic approaches.
Antidepressants and gabapentinoids are the first-line treatment options. Self-management strategies, exercise and neuromodulation are the non-pharmacological pain management options.
Advanced neurophysiological and neuroimaging techniques are used to understand of mechanisms that underlie central neuropathic pain and as predictive biomarkers of treatment outcome.
