Coagulation factor X and prostate cancer
The researchers demonstrate the release of coagulation factor X (FX) in the tumor microenvironment of castration resistant prostate cancer by CD84+ immunosuppressive PMNs.
FX promotes androgen independent cell proliferation and therapy resistance, independently from the coagulation cascade, by binding PAR2 on prostate cancer cells.
This research reveals a new interplay between coagulation factors, immune cells, and cancer.
https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00317-9
https://sciencemission.ayurmatrika.com/Coagulation-factor-X-promotes-resistance-to-androgen-deprivation-therapy-in-prostate-cancer
