Gut-brain cytokine signaling via glia couples sleep to intestinal inflammation

The researchers show that under homeostatic conditions, enteroendocrine cells (EECs) release baseline levels of Unpaired, which interacts with the blood-brain barrier (BBB) to maintain normal JAK-STAT signaling, promoting healthy wakefulness.

In response to disease, reactive oxygen species (ROS) increase in EECs, leading to elevated release of Unpaired. This surge in Unpaired upregulates JAK-STAT signaling in BBB glia, which inhibits wake-promoting AstA signaling by suppressing AstA receptors, thus resulting in increased sleep, a state termed 'sickness-sleep,' to promote recovery.

https://www.biorxiv.org/content/10.1101/2024.06.25.600726v1

https://sciencemission.ayurmatrika.com/Glia-mediated-gut-brain-cytokine-signaling-couples-sleep-to--intestinal-inflammation