Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant phenotypes

Brain-resident microglia and peripheral macrophages play key roles in neurodegenerative diseases such as Alzheimer’s disease (AD).

The researchers describe a cytokine-induced model of disease-associated microglia/lipid-associated macrophages (DLAMs).

Through transcriptomic and functional profiling of cytokine mix-treated THP-1 macrophages, they reveal a transition to the DLAM state, modulation of AD risk genes, and alterations in metabolism, lysosomal activity, and lipid homeostasis, providing insights into AD-related mechanisms.

https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00680-1

https://sciencemission.com/Cytokine-induced-reprogramming-of-human-macrophages-toward-AD