Degrading RNA with Precision
Compartmentalized helicase–exosome complexes confer spatiotemporal specificity in nuclear and cytoplasmic RNA decay, preventing toxic transcript accumulation.
Conformational gating ensures 3′ → 5′ RNA degradation is selectively activated by ribosome stalling, safeguarding functional mRNAs.
Epitranscriptomic marks act as central signals for decay, recruiting exosome adaptors and directing nuclear/cytoplasmic surveillance of noncoding RNAs.
Exosomopathies and cancer vulnerabilities arise from mutations in exosome cofactors, exposing therapeutic targets.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(26)00063-2
