Driving factors of neuronal ferroptosis

Ferroptosis is a type of cell death triggered by the iron-dependent accumulation of lipid peroxides.

Neurons are rich in phospholipids containing polyunsaturated fatty acids and iron, likely sensitizing them to ferroptosis.

Healthy neurons have mechanisms to protect them from lipid peroxidation, while in disease, these defenses are compromised, ultimately favoring ferroptosis.

A tight link exists between ferroptosis and toxic protein deposition in neurodegenerative disease.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00022-9

https://sciencemission.ayurmatrika.com/Driving-factors-of-neuronal-ferroptosis