Dual role of SOX2 in cell fate regulation

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Dual role of SOX2 in cell fate regulation

SOX2 is a gene regulator and world famous for its importance for stem cells.

Based on observations in cancer cells, the researchers now propose a revised understanding of SOX2 action where gene regulation in the nucleus and protein synthesis in association with cytosolic ribosomes jointly regulate cell fate.

https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01158-6

https://sciencemission.ayurmatrika.com/Nuclear-and-cytosolic-fractions-of-SOX2-synergize-as-transcriptional-and-translational-co-regulators-of-cell-fate