Metabolic vulnerabilities of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an adult neurodegenerative disease leading to progressive muscle weakness and atrophy.
Metabolic alterations are widely associated with the onset of ALS. Beyond motor neurons, other central and peripheral tissues contribute to metabolic dysfunctions in ALS.
Early weight loss in patients with ALS may indicate a worse prognosis.
Targeting energy metabolism could represent a promising therapeutic approach for ALS.
Therapeutic strategies targeting energy metabolism should consider both central and peripheral organs to effectively address the multifaceted nature of ALS.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(25)00044-X
