Dysregulation of neuroimmune crosstalk in neurodegeneration
Neurodegeneration is increasingly recognized as a breakdown of communication between the nervous and immune systems rather than a purely isolated neuronal disorder.
Historically, neuroinflammation was thought to be a passive, secondary consequence of neuronal death. However, emerging research—highlighted in this perspective, establishes that chronic diseases like Alzheimer’s, Parkinson’s, and ALS are inherently driven by a failure of neuroimmune crosstalk, where vital protective circuits are lost and self-reinforcing, maladaptive inflammatory loops take over.
Under this paradigm, the immune system acts as both a sensor and an active driver of brain health across the lifespan.
https://www.cell.com/cell/fulltext/S0092-8674%2826%2900813-5
