Epstein–Barr virus hijacks host B cell metabolism

Epstein–Barr virus (EBV) exploits B cell biology by mimicking natural B cell metabolic remodeling to activate B cells, drive them into proliferation and transformation, and eventually establish persistent infection in memory B cells. 

To support different stages of its life cycle, EBV strategically manipulates host B cell metabolism with respect to glycolysis, oxidative phosphorylation (OxPhos), and nucleotide and lipid metabolism.

EBV’s ability to subvert B cell metabolism is linked to various EBV-associated diseases, including lymphoproliferative disorders and cancers, underscoring the need for targeted therapeutic strategies.

Exploring and comparing the metabolic mechanisms underlying EBV-induced B cell transformation from normal B cell differentiation might help uncover virus specific metabolic targets for developing more effective treatments against EBV associated pathologies.

https://www.cell.com/trends/immunology/fulltext/S1471-4906(24)00296-5

https://sciencemission.com/pstein%E2%80%93Barr-virus-hijacks-B-cell-metabolism