EGF-mediated Golgi dynamics and cell migration require CARP2
The researchers demonstrate that Golgi dispersal and cell motility reported upon EGF stimulation require CARP2.
CARP2, an endosomal ubiquitin ligase, targets Golgin45 for ubiquitination and degradation, leading to Golgi dispersal.
CARP2 knockout cells exhibit reduced Golgi dispersal and motility in response to EGF.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01247-6
https://sciencemission.com/EGF-mediated-Golgi-dynamics-and-cell-migration-require-CARP2
