Ebola virus transcription and egress regulation by Hippo signaling pathway
At various stages of the Filovirus lifecycle, it interacts with the host to survive and grow.
The researchers demonstrate that Hippo pathway components, LATS1/2 kinases and YAP, regulate EBOV transcription and egress. They show that when YAP is phosphorylated by LATS1/2, it localizes to the cytoplasm (Hippo “ON”) where it sequesters VP40 to prevent egress. In contrast, when the Hippo pathway is “OFF”, unphosphorylated YAP translocates to the nucleus where it transcriptionally activates host genes and promotes viral egress.
They also show that LATS2 indirectly modulates filoviral VP40- mediated egress through phosphorylation of AMOTp130, a positive regulator of viral egress, but more surprisingly that LATS1/2 kinases directly modulate EBOV transcription by phosphorylating VP30, an essential regulator of viral transcription.
The authors believe that the Hippo pathway/filovirus axis could be exploited for targeting EBOV and related filoviruses.
https://www.nature.com/articles/s41467-024-51356-z
https://sciencemission.com/Hippo-signaling-pathway-regulates-Ebola-virus-transcription-and-egress