Pregnancy circadian rhythm dictate metabolic plasticity in offspring

 16
Pregnancy circadian rhythm dictate metabolic plasticity in offspring

The researchers wanted to figure out if maternal circadian rhythms during pregnancy influence fetal rhythms and impact long-term susceptibility to dietary challenges in offspring.

The researchers demonstrate that maternal circadian rhythms during pregnancy does impact placental signature and fetal rhythm. The authors show that circadian disruption during pregnancy decreased placental and neonatal weight yet retained transcriptional and structural maturation.

Diet-induced obesity in offspring is exacerbated by in utero chrono-disruption.

The obesity exacerbation is not fully prevented by temporal feeding restriction but is counteracted by caloric restriction with daily food replacement.

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00484-4

https://sciencemission.com/pregnancy--circadian-rhythm-and-offspring