Endomembrane GPCR signaling
G-protein-coupled receptors (GPCRs) initiate classical G-protein-mediated signaling on membranes of intracellular organelles, such as endosomes or the Golgi.
A growing number of GPCRs have been shown to initiate endomembrane G-protein-mediated signaling.
Trafficking and signaling form intracellular membranes result in unique spatiotemporal signaling patterns.
Endomembrane signaling appears to be required for efficient GPCR signaling and downstream physiological responses.
Understanding the mechanisms of endomembrane GPCR signaling could pave the way to more effective and selective drugs.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(24)00231-7
https://sciencemission.com/Endomembrane-GPCR-signaling:-15-years-on,-the-quest-continues
