Exercise as Mitochondrial Medicine

In addition to energy transformation, mitochondria have several functions including cell signaling, calcium homeostasis, hormone synthesis, programmed cell death (apoptosis), and others. 

Mitochondria respond and adapt to various stressors and the stress of exercise provides a powerful stimulus that can trigger transient or enduring changes to mitochondrial molecular features, activities, integrated functions, behaviors, and cell-dependent mitochondrial phenotypes.

There are many beneficial effects of mitochondrial adaptations to exercise and importance of mitochondrial medicine, it is necessary to understand the optimal prescription (i.e., type, dose, frequency, duration).

In this review, the researchers  build on a systematic biological framework that distinguishes between domains of mitochondrial biology to critically evaluate how different exercise prescription variables influence mitochondrial adaptations to training.

https://www.annualreviews.org/content/journals/10.1146/annurev-physiol-022724-104836

https://sciencemission.com/Exercise-as-Mitochondrial-Medicine