Exercise rewires liver metabolism differently based on sex
Exercise benefits nearly every part of the body, including the liver and metabolism. But, new research suggests those benefits may not look the same in males and females.
The researchers found endurance exercise altered how liver cells created energy, a process known as the Krebs cycle that happens inside individual cells in the mitochondria. Female rats had more proteins created with the energy cycle, whereas male rats had more proteins modified, or remodeled, by a chemical reaction that triggers the cycle.
“Male and female liver cells adapt to endurance exercise through distinct molecular pathways, which remodels the cellular structures responsible for producing energy. Think of it like female rats generated more proteins, while male rats changed more of their existing proteins,” the senior author said. “These are subtle changes in the cellular energy process, and one sex doesn’t necessarily have a ‘better’ modification.”
The team found that exercise training improved liver health in both sexes – there was reduced liver fat, improved cholesterol use and disposal, and fewer markers of fibrosis, which is a buildup of scar tissue typically seen with liver injury or disease. Males specifically seemed to expel more cholesterol from the body than females.
“Why these different adaptations occur is still unclear, but we plan on investigating how these changes in the cell energy cycle might affect metabolism, which is how the body creates and uses energy,” the author said. “Our findings indicate that endurance and consistent exercise improve metabolic ‘machinery.’ What else we could discover may provide more precise and personalized interventions for people with metabolic dysfunction-associated steatotic liver disease, or MASLD.”
MASLD, previously called nonalcoholic fatty liver disease, is the most common chronic liver disease, especially as the number of people diagnosed with obesity rises. The most severe forms can lead to cancer or cirrhosis, which can both be fatal.
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00494-8
https://sciencemission.com/exercise-elicits-temporal
