Extracellular vesicles from the apoptotic cells

Apoptotic cells can release a variety of soluble factors as well as apoptotic-cell derived extracellular vesicle (ApoEV)- associated biomolecules to orchestrate key downstream processes following cell death.

Recent advances have expanded our understanding of the molecular mechanisms underpinning ApoEV formation, packaging of cargos within/on ApoEVs, and the role of ApoEVs in physiological and pathological settings.

Advances in microscopy studies have captured the biogenesis of ApoEVs and their interaction with recipient cells in vivo. Biogenesis of ApoBDs could be modulated pharmacologically, demonstrating the potential in therapeutically targeting this process in diseases associated with apoptotic cell death, in particular viral infections.

ApoEVs are emerging as novel cell-free therapeutics for a broad range of diseases through their ability in modulating tissue repair and immune processes.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00205-8

https://sciencemission.com/Extracellular-vesicles-from-the-dead:-the-final-message