Forebrain assembloids to study schizophrenia-associated defects
Implicated in schizophrenia pathogenesis are disruption of parvalbumin positive (PVALB+) cortical interneurons but mechanism of developmental defects in interneurons are not well understood.
The researchers establish a human forebrain assembloid protocol that supports the derivation of bona fide PVALB+ cortical interneurons and employ it to model schizophrenia in disease-associated structural variants.
The authors identify disease-relevant deficits in cortical interneurons at multiple developmental stages and their ability to regulate network activity, including γ-oscillations.
