GDF15 links adipose tissue lipolysis with anxiety
Adrenaline released during stress modulates behavior and metabolism to protect organisms and can be alleviated by a peripherally restricted β-blocker.
The researchers show that adrenaline, the β3 agonist CL316,243 and acute restraint stress induce growth differentiation factor 15 (GDF15) secretion in white adipose tissue. They also demonstrate that increases in circulating GDF15 require lipolysis-induced free fatty acid stimulation of M2-like macrophages within white adipose tissue..
Inhibition of adipose triglyceride lipase or genetic deletion of β-adrenergic receptors blocks β-adrenergic-induced increases in GDF15.
The authors show that anxiety-like behavior elicited by adrenaline or restraint stress is eliminated in mice lacking the GDF15 receptor GFRAL.
