Histamine synthesis and transport to axon terminals and neurotransmission

Neurotransmitters are key for synaptic transmission at axon terminals, but their transport modalities remain debated. 

This study shows that coupling histamine synthesis with synaptic vesicle loading is critical for neurotransmitter homeostasis and synaptic transmission.

The authors demonstrate that histidine decarboxylase (HDC) is co-transported with synaptic vesicles to axonal terminals through binding with vesicle-fusing ATPase NSF1.

Remaining HDC in soma is degraded by the E3 ubiquitin ligase POE via the proteasome.

Aberrant accumulation of histamine in the soma is cytotoxic and causes retinal degeneration.

https://www.embopress.org/doi/full/10.1038/s44318-024-00223-0

https://sciencemission.ayurmatrika.com/Histamine-synthesis-and-transport-are-coupled-in-axon-terminals-via-a-dual-quality-control-system