Plasma neurofilament light chain assay for preclinical and mild Alzheimer’s disease

The researchers report data from a new immunoprecipitation-mass spectrometry assay for measuring plasma neurofilament light chain (NfL) peptides.

The researchers observed elevated neurofilament light chain in preclinical Alzheimer’s disease plasma for two measures (NfL101 and NfL324) and CSF for seven measures (NfL92, NfL101, NfL117, NfL137, NfL148, NfL165 and NfL530).

They also found five plasma peptides (NfL92, NfL101, NfL117, NfL324 and NfL530) significantly associated with age and two (NfL148 and NfL324) with body mass index.

https://academic.oup.com/braincomms/article/6/4/fcae247/7736988

https://sciencemission.ayurmatrika.com/Multi-peptide-characterization-of-plasma-neurofilament-light-chain-in-preclinical-and-mild-Alzheimer%E2%80%99s-disease