How gut Bacteroides ovatus ameliorates renal fibrosis
The researchers describe that Bacteroides ovatus increases the production of hyodeoxycholic acid by upregulating Clostridium scindens.
Hyodeoxycholic acid promotes the secretion of GLP-1, which activates the renal GLP-1 receptor, ameliorating chronic kidney disease.
Neohesperidin, as a prebiotic, regulates the abundance of B. ovatus, contributing to the improvement of CKD.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01181-1
